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Article

Diversity in Polygenic Risk of Primary Open-Angle Glaucoma.

Genes - 30 Dec 2022

Cooke Bailey Jessica N, Funk Kaitlyn L, Cruz Lauren A, Waksmunski Andrea R, Kinzy Tyler G, Wiggs Janey L, Hauser Michael A

Abstract excerpt

Glaucoma is the leading cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), the most common glaucoma subtype, is more prevalent and severe in individuals of African ancestry. Unfortunately, this ancestral group has been historically under-represented among genetic studies of POAG. Moreover, both genetic and polygenic risk scores (GRS, PRS) that are typically based on genetic data from...

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Identifiers

PMID: 36672852
DOI: 10.3390/genes14010111
PMCID: PMC9859496

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