Article
The Clinical Usefulness of a Glaucoma Polygenic Risk Score in 4 Population-Based European Ancestry Cohorts.
Ophthalmology - 1 Feb 2025
de Vries Victor A, Hanyuda Akiko, Vergroesen Joëlle E, Do Ron, Friedman David S, Kraft Peter, Turman Constance, Luo Yuyang Leo, Tran Jessica H, Liefers Bart, Wong Sze H, Lee Rachel H, Zebardast Nazlee, Klaver Caroline C W, Segrè Ayellet V, Pasquale Louis R, Wiggs Janey L, Kang Jae H, Ramdas Wishal D
Abstract excerpt
PURPOSE: We used a polygenic risk score (PRS) to identify high-risk groups for primary open-angle glaucoma (POAG) within population-based cohorts. DESIGN: Secondary analysis of 4 prospective population-based studies. PARTICIPANTS: We included four European-ancestry cohorts: the United States-based Nurses' Health Study, Nurses' Health Study 2, and the Health Professionals Follow-up Study and the Rotterdam Study...
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