Article

A Budding Yeast Model and Screen to Define the Functional Consequences of Oncogenic Histone Missense Mutations

2021-10-02

Abstract excerpt

<h4>ABSTRACT</h4> Somatic missense mutations in histone genes turn these essential proteins into oncohistones, which can drive oncogenesis. Understanding how missense mutations alter histone function is challenging in mammals as mutations occur in a single histone gene. For example, described oncohistone mutations predominantly occur in the histone H3.3 gene, despite the human genome encoding 15 H3 genes. To und...

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Literature Corpus work: fccef4c2-c6e8-5b92-86a4-2fdfbe46f1a4
DOI: 10.1101/2021.10.02.462853

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