Article
Histone mutations in cancer.
Biochemical Society transactions - 31 Oct 2023
Espinoza Pereira Kimberly N, Shan Jixiu, Licht Jonathan D, Bennett Richard L
Abstract excerpt
Genes encoding histone proteins are recurrently mutated in tumor samples, and these mutations may impact nucleosome stability, histone post-translational modification, or chromatin dynamics. The prevalence of histone mutations across diverse cancer types suggest that normal chromatin structure is a barrier to tumorigenesis. Oncohistone mutations disrupt chromatin structure and gene regulatory mechanisms,...
Topics
- Humans
- Child
- Histones
- Nucleosomes
- Mutation
- Neoplasms
- Chromatin
- Carcinogenesis
- Cell Transformation, Neoplastic