Article

Phenotypic and Functional Characterization of Oncohistone Mutations in Breast Cancers

2025-05-03

Abstract excerpt

Although mutations in genes encoding histones display a similar prevalence to that of some other somatic mutations in cancer, the underlying mechanisms by which histone mutations drive tumorigenesis have not been fully explored. Herein, we curated missense mutations occurring in core histone genes in breast cancers using data from MSK-IMPACT and cBioPortal to identify high frequency breast cancer-associated histon...

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Literature Corpus work: 8b5cd047-bd27-5c59-8046-4799f9613b60
DOI: 10.1101/2025.04.29.651098

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