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Overexpression of Eaf1, a subunit of the NuA4 lysine acetyltransferase complex, rescues growth defects in the <i>Saccharomyces cerevisiae</i> H3K36M oncohistone model via histone H4 tail acetylation

2026-06-01

Abstract excerpt

Histone proteins are critical for regulating nucleic acid transactions, including gene expression. Specific missense mutations in histone genes have been linked to oncogenesis, creating oncohistones. One of the first identified oncohistones converts K36 in histone H3 to M (H3K36M). While humans have 15 H3 genes, the Saccharomyces cerevisiae genome contains only two H3 genes. As H3 shares 90% sequence identity bet...

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Literature Corpus work: 94dde892-c8d3-55a1-9a86-370e6d33bc5c
DOI: 10.64898/2026.05.30.728992

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Overexpression of Eaf1, a subunit of the NuA4 lysine acetyltransferase complex, rescues growth defects in the <i>Saccharomyces cerevisiae</i> H3K36M oncohistone model via histone H4 tail acetylationDOI 10.64898/2026.05.30.728992Read

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