Article
A Saccharomyces cerevisiae model and screen to define the functional consequences of oncogenic histone missense mutations.
G3 (Bethesda, Md.) - 6 Jul 2022
Lemon Laramie D, Kannan Sneha, Mo Kim Wai, Adams Miranda, Choi Haley G, Gulka Alexander O D, Withers Elise S, Nurelegne Hasset T, Gomez Valeria, Ambrocio Reina E, Tumminkatti Rhea, Lee Richard S, Wan Morris, Fasken Milo B, Spangle Jennifer M, Corbett Anita H
Abstract excerpt
Somatic missense mutations in histone genes turn these essential proteins into oncohistones, which can drive oncogenesis. Understanding how missense mutations alter histone function is challenging in mammals as mutations occur in a single histone gene. For example, described oncohistone mutations predominantly occur in the histone H3.3 gene, despite the human genome encoding 15 H3 genes. To understand how...
Topics
- Animals
- Caffeine
- Carcinogenesis
- Histone Acetyltransferases
- Histones
- Humans
- Mammals
- Mutation
- Mutation, Missense
- Saccharomyces cerevisiae