Article

Surprising Phenotypic Diversity of Cancer-associated mutations of Gly 34 in the Histone H3 tail

2020-12-11

Abstract excerpt

Sequencing of cancer genomes has identified recurrent somatic mutations in histones, termed oncohistones, which are frequently poorly understood. Previously we showed that fission yeast expressing only the H3.3G34R mutant identified in aggressive pediatric glioma had reduced H3K36 trimethylation and acetylation, increased genomic instability and replicative stress, and defective homology-dependent DNA damage repai...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b711c8c3-f3a4-5ff1-b5a9-7ad72e2c0718
DOI: 10.1101/2020.12.10.419184

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Surprising Phenotypic Diversity of Cancer-associated mutations of Gly 34 in the Histone H3 tailDOI 10.1101/2020.12.10.419184Read

A Budding Yeast Model and Screen to Define the Functional Consequences of Oncogenic Histone Missense MutationsSemantic proximity Read

A Saccharomyces cerevisiae model and screen to define the functional consequences of oncogenic histone missense mutations.Semantic proximity Read

Histone H3 mutations--a special role for H3.3 in tumorigenesis?Semantic proximity Read

Base-resolution methylomes of gliomas bearing histone H3.3 mutations reveal a G34 mutant-specific signature shared with bone tumors.Semantic proximity Read

Exploring the Molecular Underpinnings of Cancer-Causing Oncohistone Mutants Using Yeast as a ModelSemantic proximity Read

Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis.Semantic proximity Read

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.Semantic proximity Read

Histone H3 E50K mutation confers oncogenic activity and supports an EMT phenotypeSemantic proximity Read

G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails.Semantic proximity Read

Histone Variant H3.3 Mutations in Defining the Chromatin Function in Mammals.Semantic proximity Read

Globally altered epigenetic landscape and lagging osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of boneSemantic proximity Read

The histone variant H3.3 G34W substitution in giant cell tumor of the bone link chromatin and RNA processing.Semantic proximity Read