Article

Histone H3 E50K mutation confers oncogenic activity and supports an EMT phenotype

2023-10-12

Abstract excerpt

Sequencing of human patient tumors has identified recurrent missense mutations in genes encoding core histones. We report that mutations that convert histone H3 amino acid 50 from a glutamate to a lysine (H3E50K) support an oncogenic phenotype in human cells. Expression of H3E50K is sufficient to transform human cells as evidenced by a dramatic increase in cell migration and invasion, and a statistically significa...

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Literature Corpus work: f50f773b-e8f1-59b2-97f6-a2b5a97129c0
DOI: 10.1101/2023.10.11.561775

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