Article

Multiomic screening platform uncovers the impact of histone mutations on chromatin and cell fate

2026-04-17

Abstract excerpt

Somatic missense mutations in histone genes, often referred to as ‘oncohistones’, have been identified in diverse types of human cancers. The functional and mechanistic impact of most oncohistones remains unknown. To address this gap, we developed CHANCLA, a modular platform for high-throughput functional screening of oncohistones using multiomic phenotypic readouts. We used CHANCLA to systematically measure the i...

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Literature Corpus work: 0c5f7d32-f5c0-5947-89bd-98289fbaa941
DOI: 10.64898/2026.04.14.718582

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