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Article

Histone Variant H3.3 Mutations in Defining the Chromatin Function in Mammals.

Cells - 18 Dec 2020

Trovato Matteo, Patil Vibha, Gehre Maja, Noh Kyung Min

Abstract excerpt

The systematic mutation of histone 3 (H3) genes in model organisms has proven to be a valuable tool to distinguish the functional role of histone residues. No system exists in mammalian cells to directly manipulate canonical histone H3 due to a large number of clustered and multi-loci histone genes. Over the years, oncogenic histone mutations in a subset of H3 have been identified in humans, and have advanced our...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 33353064
DOI: 10.3390/cells9122716
PMCID: PMC7766983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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