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Discovery of Proteoforms Associated With Alzheimer's Disease Through Quantitative Top-Down Proteomics

5 May 2025

Abstract excerpt

The complex nature of Alzheimer's disease (AD) and its heterogenous clinical presentation has prompted numerous large-scale -omic analyses aimed at providing a global understanding of the pathophysiological processes involved. AD involves isoforms, proteolytic products, and posttranslationally modified proteins such as amyloid beta (Aβ) and microtubule-associated protein tau. Top-down proteomics directly measures...

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PMID: 40334744
DOI: 10.1016/j.mcpro.2025.100983

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