Article
Human-mouse proteomics reveals the shared pathways in Alzheimer’s disease and delayed protein turnover in the amyloidome
2024-10-25
Abstract excerpt
Murine models of Alzheimer’s disease (AD) are crucial for elucidating disease mechanisms but have limitations in fully representing AD molecular complexities. We comprehensively profiled age-dependent brain proteome and phosphoproteome ( n > 10,000 for both) across multiple mouse models of amyloidosis. We identified shared pathways by integrating with human metadata, and prioritized novel components by multi-omic...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- b241f0e1-d397-5c71-886f-4c6fbdabc1f2
- DOI
- 10.1101/2024.10.25.620263