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Article

Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome‐blocking complexes

16 Dec 2014

Abstract excerpt

Age-dependent neurodegenerative diseases progressively form aggregates containing both shared components (e.g., TDP-43, phosphorylated tau) and proteins specific to each disease. We investigated whether diverse neuropathies might have additional aggregation-prone proteins in common, discoverable by proteomics. Caenorhabditis elegans expressing unc-54p/Q40::YFP, a model of polyglutamine array diseases such as...

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PMID: 25510159
DOI: 10.1111/acel.12296

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