Article

Specific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma

2023-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Diffuse midline glioma (DMG) is a fatal childhood brain tumour characterised primarily by mutant histone H3 (H3K27M). H3K27M causes a global reduction in Polycomb Repressive Complex 2 (PRC2)-mediated H3K27me3 by inhibiting PRC2 enzymatic activity. Paradoxically, PRC2 is essential in DMG tumour cells where residual complex activity is required for oncogenic gene repression, although the molecular...

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Literature Corpus work: 7818088c-bb35-589a-bb00-5f7656c73781
DOI: 10.1101/2023.12.02.569451

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