Article

Extensive long-range polycomb interactions and weak compartmentalization are hallmarks of human neuronal 3D genome

2023-08-07

Abstract excerpt

<h4>ABSTRACT</h4> Chromatin architecture regulates gene expression and shapes cellular identity, particularly in neuronal cells. Specifically, polycomb group (PcG) proteins enable establishment and maintenance of neuronal cell type by reorganizing chromatin into repressive domains that limit the expression of fate-determining genes and sustain distinct gene expression patterns in neurons. Here, we map the 3D geno...

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Literature Corpus work: fd3ea59b-2da9-5181-b121-a4a330b0a902
DOI: 10.1101/2023.08.04.551939

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