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Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation

28 Jan 2021

Abstract excerpt

To investigate the three-dimensional (3D) genome architecture across normal B cell differentiation and in neoplastic cells from different subtypes of chronic lymphocytic leukemia and mantle cell lymphoma patients, here we integrate in situ Hi-C and nine additional omics layers. Beyond conventional active (A) and inactive (B) compartments, we uncover a highly-dynamic intermediate compartment enriched in poised and...

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PMID: 33510161
DOI: 10.1038/s41467-020-20849-y

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