Article

Polycomb-mediated Genome Architecture Enables Long-range Spreading of H3K27 methylation

2020-07-27

Abstract excerpt

<h4>SUMMARY</h4> Polycomb-group proteins play critical roles in gene silencing through the deposition of histone H3 lysine 27 trimethylation (H3K27me3) and chromatin compaction 1-5 . This process is essential for embryonic stem cell (ESCs) pluripotency, differentiation, and development. Polycomb repressive complex 2 (PRC2) can both read and write H3K27me3, enabling progressive spread of H3K27me3 on the linear ge...

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Literature Corpus work: 1e3745c5-a6c4-5259-8fbf-6e59624c3dbc
DOI: 10.1101/2020.07.27.223438

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