Article

PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism

2019-03-22

Abstract excerpt

<h4>ABSTRACT</h4> Polycomb group (PcG) proteins are essential for development and are frequently misregulated in human cancers. Polycomb Repressive Complexes (PRC1, PRC2) function in a collaborative epigenetic cross-talk with H3K27me3 to initiate and maintain transcriptional silencing. Diffuse intrinsic pontine gliomas (DIPGs) have extremely low H3K27me3 levels mediated by H3 K27M oncohistone. Posterior fossa typ...

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Literature Corpus work: 2851eab4-0eaa-5ea6-8098-89a9408a519b
DOI: 10.1101/585729

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