Article

State-dependent geometric constraints reveal a regulatory gate in hematopoietic progenitors

2026-01-01

Abstract excerpt

Single-cell multiome technologies have revealed geometric constraints in the joint distribution of chromatin accessibility and gene expression—regions termed “forbidden zones” that are systematically underpopulated. These patterns are particularly prominent in progenitor cells, leading to interpretations that developmental plasticity involves reduced informational coupling between epigenetic and transcriptional la...

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Literature Corpus work: fc1ccf8a-7bb7-53d2-b5d1-41f4feac20c4
DOI: 10.64898/2025.12.31.697210

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