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Article

MIR retrotransposons link the epigenome and the transcriptome of coding genes in acute myeloid leukemia.

Nature communications - 31 Oct 2022

Telonis Aristeidis G, Yang Qin, Huang Hsuan-Ting, Figueroa Maria E

Abstract excerpt

DNMT3A and IDH1/2 mutations combinatorically regulate the transcriptome and the epigenome in acute myeloid leukemia; yet the mechanisms of this interplay are unknown. Using a systems approach within topologically associating domains, we find that genes with significant expression-methylation correlations are enriched in signaling and metabolic pathways. The common denominator across these methylation-regulated...

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Identifiers

PMID: 36316347
DOI: 10.1038/s41467-022-34211-x
PMCID: PMC9622910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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