Article

The basal level of gene expression associated with chromatin loosening shapes Waddington landscapes and controls cell differentiation

2019-08-16

Abstract excerpt

The baseline level of transcription is variable and seriously complicates the normalization of comparative transcriptomic data, but its biological importance remains unappreciated. We show that this ingredient is in fact crucial for the interpretation of molecular biology results. It is correlated to the degree of chromatin loosening measured by DNA accessibility, and systematically leads to cellular dedifferentia...

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Literature Corpus work: e620f673-28a4-549b-b483-fe92ce1d47e5
DOI: 10.1101/738120

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