Article

Distinct gene regulatory networks govern hematopoietic and leukemia stem cells

2024-09-30

Abstract excerpt

The underlying gene regulatory networks (GRN) that govern leukemia stem cells (LSC) in acute myeloid leukemia (AML) and hematopoietic stem cells (HSC) are not well understood. Here, we identified GRNs by integrating gene expression (GE) and chromatin accessibility data derived from functionally defined cell populations enriched for HSC and LSC. We analyzed n=32 LSC+ and n=32 LSC-cell fractions from n=22 AML patien...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6828cdb-bd92-56a9-bffb-f4ab84ea602f
DOI: 10.1101/2024.09.28.614980

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct gene regulatory networks govern hematopoietic and leukemia stem cellsDOI 10.1101/2024.09.28.614980Read

Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cellsSemantic proximity Read

Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cellsSemantic proximity Read

A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemiaSemantic proximity Read

Trimodal Single-Cell Gene Regulatory Networks Reveal Principles of Stemness Loss and Cell Fate Acquisition in Human HematopoiesisSemantic proximity Read

A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemiaSemantic proximity Read

Dysregulated gene expression networks in human acute myelogenous leukemia stem cellsSemantic proximity Read

A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genomeSemantic proximity Read

Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human developmentSemantic proximity Read

Molecular landscapes of human hematopoietic stem cells in health and leukemiaSemantic proximity Read

Cell-cell interactome of the hematopoietic niche and its changes in acute myeloid leukemiaSemantic proximity Read

Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activationSemantic proximity Read

Single-cell epigenomics maps the continuous regulatory landscape of human hematopoietic differentiationSemantic proximity Read