Article

SCOPE: Localizing fate-decision states and their regulatory drivers in single-cell differentiation

2026-04-09

Abstract excerpt

Identifying the precise transcriptomic states at which cells commit to a lineage (branchpoints) and the temporal lag in which chromatin accessibility foreshadows gene expression (epigenetic priming) remain fundamental challenges in developmental biology. While current methods for single-cell sequencing data effectively capture developmental flow, they often lack a principled mechanism for delineating the discrete...

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Literature Corpus work: adde5d29-05f9-50e6-a48b-6fd44202814b
DOI: 10.64898/2026.04.07.717037

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