Article

Echo characterizes the desynchronization of gene expression and chromatin accessibility during cell-state transitions

2026-05-22

Abstract excerpt

Cell-state transitions during differentiation and disease involve coordinated changes across gene expression and chromatin accessibility, but these modalities do not change in lockstep. For example, regulatory elements can be primed before their target genes are expressed or remain accessible after expression ceases. This desynchronization between changes in gene expression and chromatin accessibility can manifest...

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Literature Corpus work: 2a230e1e-1bcb-5458-b9c6-f9d609061c0a
DOI: 10.64898/2026.05.20.726634

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