Article
Multiple fates of L1 retrotransposition intermediates in cultured human cells.
Molecular and cellular biology - 1 Sept 2005
Gilbert Nicolas, Lutz Sheila, Morrish Tammy A, Moran John V
Abstract excerpt
LINE-1 (L1) retrotransposons comprise approximately 17% of human DNA, yet little is known about L1 integration. Here, we characterized 100 retrotransposition events in HeLa cells and show that distinct DNA repair pathways can resolve L1 cDNA retrotransposition intermediates. L1 cDNA resolution can lead to various forms of genetic instability including the generation of chimeric L1s, intrachromosomal deletions,...
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