Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Active human retrotransposons: variation and disease.

Current opinion in genetics & development - 1 Jun 2012

Hancks Dustin C, Kazazian Haig H

Abstract excerpt

Mobile DNAs, also known as transposons or 'jumping genes', are widespread in nature and comprise an estimated 45% of the human genome. Transposons are divided into two general classes based on their transposition intermediate (DNA or RNA). Only one subclass, the non-LTR retrotransposons, which includes the Long INterspersed Element-1 (LINE-1 or L1), is currently active in humans as indicated by 96 disease-causing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alu Elements
Share to DNA Transposable Elements
Share to Genetic Diseases, Inborn

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Long Interspersed Nucleotide Elements

Share to Open Reading Frames

Share to Pseudogenes

Share to Untranslated Regions

Source

Open in PubMed Open full text

Identifiers

PMID: 22406018
DOI: 10.1016/j.gde.2012.02.006
PMCID: PMC3376660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Active human retrotransposons: variation and disease.PMID 22406018Read ↗

LINE-1 elements in structural variation and disease.Semantic proximity Read ↗

Human LINE-1 retrotransposons: impacts on the genome and regulation by host factors.Semantic proximity Read ↗

The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes.Semantic proximity Read ↗

The impact of retrotransposons on human genome evolution.Semantic proximity Read ↗

A comprehensive identification and annotation of mobile LINE-1 retrotransposons across human reference and personal genomesSemantic proximity Read ↗

euL1db: the European database of L1HS retrotransposon insertions in humans.Semantic proximity Read ↗

Active Alu retrotransposons in the human genome.Semantic proximity Read ↗

Mobile elements and diseaseSemantic proximity Read ↗

Natural genetic variation caused by transposable elements in humans.Semantic proximity Read ↗

Retrotransposon life cycle and its impacts on cellular responsesSemantic proximity Read ↗

Comprehensive scanning mutagenesis of human retrotransposon LINE-1 identifies motifs essential for functionSemantic proximity Read ↗

Assessment of genetic variation for the LINE-1 retrotransposon from next generation sequence data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.