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Article

The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes.

Microbiology spectrum - 1 Apr 2015

Richardson Sandra R, Doucet Aurélien J, Kopera Huira C, Moldovan John B, Garcia-Perez José Luis, Moran John V

Abstract excerpt

Transposable elements have had a profound impact on the structure and function of mammalian genomes. The retrotransposon Long INterspersed Element-1 (LINE-1 or L1), by virtue of its replicative mobilization mechanism, comprises ∼17% of the human genome. Although the vast majority of human LINE-1 sequences are inactive molecular fossils, an estimated 80-100 copies per individual retain the ability to mobilize by a...

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Identifiers

PMID: 26104698
DOI: 10.1128/microbiolspec.MDNA3-0061-2014
PMCID: PMC4498412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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