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Article

Reprogramming somatic cells into iPS cells activates LINE-1 retroelement mobility

11 Oct 2011

Abstract excerpt

Long interspersed element-1 (LINE-1 or L1) retrotransposons account for nearly 17% of human genomic DNA and represent a major evolutionary force that has reshaped the structure and function of the human genome. However, questions remain concerning both the frequency and the developmental timing of L1 retrotransposition in vivo and whether the mobility of these retroelements commonly results in insertional and...

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PMID: 21989055
DOI: 10.1093/hmg/ddr455

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