Article

The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition

2024-02-01

Abstract excerpt

<h4>ABSTRACT</h4> Repression of retrotransposition is crucial for the successful fitness of a mammalian organism. The domesticated transposon protein L1TD1, derived from LINE-1 (L1) ORF1p, is an RNA-binding protein that is expressed only in some cancers and early embryogenesis. In human embryonic stem cells, it is found to be essential for maintaining pluripotency. In cancer, L1TD1 expression is highly correlativ...

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Literature Corpus work: 8c3ed9ce-18ea-59da-819e-a19739bb0caf
DOI: 10.1101/2024.02.01.577722

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