Article

Specific properties of shRNA-mediated CCR5 downregulation that enhance the inhibition of HIV-1 infection in combination with shRNA targeting HIV-1 rev

2021-03-01

Abstract excerpt

<title>Abstract</title> <p>Treatment with RNAi against HIV-1 transcripts efficiently inhibits viral replication but induces selection of escape mutants; therefore, the CCR5 coreceptor was suggested as an additional target. Blocking viral and host transcripts improved the antiviral effect. We have used short hairpin RNA (shRNA) targeting the human CCR5 (shCCR5) or the HIV-1 rev (shRev) transcripts to demonstrate d...

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Literature Corpus work: fb9a1116-56a8-54e1-b2e5-08458f3d9fff
DOI: 10.21203/rs.3.rs-171805/v1

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