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Article

Inhibition of HIV‐1 infection by a unique short hairpin RNA to chemokine receptor 5 delivered into macrophages through hematopoietic progenitor cell transduction

24 Feb 2010

Abstract excerpt

BACKGROUND: We recently expressed a potent and noncytotoxic short hairpin (sh)RNA directed against chemokine (c-c motif) receptor 5 (CCR5) using lentiviral mediated transduction of CD34+ hematopoietic progenitor cells (HPCs) and demonstrated the stable reduction of CCR5 expression in T-lymphocytes. METHODS: In the present study, we further assessed the activity of the shRNA through HPC transduction and...

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PMID: 20186995
DOI: 10.1002/jgm.1440

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