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Article

RNA interference targeted to the conserved dimerization initiation site (DIS) of HIV-1 restricts virus escape mutation.

Journal of biochemistry - 1 Oct 2009

Sugiyama Ryuichi, Habu Yuichiro, Ohnari Aki, Miyano-Kurosaki Naoko, Takaku Hiroshi

Abstract excerpt

Short hairpin RNAs (shRNA) targeting viral or cellular genes can effectively inhibit human immunodeficiency virus type 1 (HIV-1) replication. This inhibition, however, may induce mutations in the targeted gene, leading to rapid escape from the shRNA-induced inhibition. We generated a lymphoid cell line that stably expressed a 19-bp shRNA targeting a well-conserved dimerization initiation site (DIS) of HIV-1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19556221
DOI: 10.1093/jb/mvp093
PMCID: PMC7539327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RNA interference targeted to the conserved dimerization initiation site (DIS) of HIV-1 restricts virus escape mutation.PMID 19556221Read ↗

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