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Article

An RNAi in silico approach to find an optimal shRNA cocktail against HIV-1.

Virology journal - 20 Dec 2010

Méndez-Ortega María C, Restrepo Silvia, Rodríguez-R Luis M, Pérez Iván, Mendoza Juan C, Martínez Andrés P, Sierra Roberto, Rey-Benito Gloria J

Abstract excerpt

BACKGROUND: HIV-1 can be inhibited by RNA interference in vitro through the expression of short hairpin RNAs (shRNAs) that target conserved genome sequences. In silico shRNA design for HIV has lacked a detailed study of virus variability constituting a possible breaking point in a clinical setting. We designed shRNAs against HIV-1 considering the variability observed in naïve and drug-resistant isolates available...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conserved Sequence

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Share to Protein Structure, Tertiary

Share to RNA Interference

Share to RNA, Small Interfering

Source

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Identifiers

PMID: 21172023
DOI: 10.1186/1743-422X-7-369
PMCID: PMC3022682

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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