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Article

Multivalent anti-CCR ribozymes for stem cell-based HIV type 1 gene therapy.

AIDS research and human retroviruses - 20 Mar 2001

Bai J, Rossi J, Akkina R

Abstract excerpt

HIV-1 infection of susceptible cells is mediated by the specific interaction of viral envelope glycoproteins with the cell surface CD4 receptor and a chemokine coreceptor, CCR5 or CXCR4. Individuals with a CCR5 genetic defect show resistance to HIV-1 infection, indicating that downregulation of C...

Read the complete abstract on PubMed

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Share to CCR5 Receptor Antagonists
Share to Chemokines, CC
Share to Genetic Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cells

Share to Immunophenotyping

Share to Receptors, CCR5

Share to RNA, Catalytic

Share to Transduction, Genetic

Source

Identifiers

PMID: 11282007
DOI: 10.1089/088922201750102427

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11282007-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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