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Computational Design of Antiviral RNA Interference Strategies That Resist Human Immunodeficiency Virus Escape

13 Jan 2005

Abstract excerpt

Recently developed antiviral strategies based upon RNA interference (RNAi), which harnesses an innate cellular system for the targeted down-regulation of gene expression, appear highly promising and offer alternative approaches to conventional highly active antiretroviral therapy or efforts to develop an AIDS vaccine. However, RNAi is faced with several challenges that must be overcome to fully realize its...

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Identifiers

PMID: 15650190
DOI: 10.1128/jvi.79.3.1645-1654.2005

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