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Article

HIV-1 resistance to the anti-HIV activity of a shRNA targeting a dual-coding region.

Virology - 15 Mar 2008

Senserrich Jordi, Pauls Eduardo, Armand-Ugón Mercedes, Clotet-Codina Imma, Moncunill Gemma, Clotet Bonaventura, Esté Jose A

Abstract excerpt

We generated a lymphoid cell line (Sup-T1-Rev/Env) that stably expresses a 19-bp short hairpin RNA (shRNA) targeting a conserved region of HIV-1 encoding for the Envelope and Rev proteins, which potently inhibited viral replication. However, continuous passage of HIV-1 in Sup-T1-Rev/Env generated virus mutants able to overcome the RNAi restriction. Sequence analysis of the emerging viruses showed that mutations...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to env Gene Products, Human Immunodeficiency Virus

Share to Genes, env

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Identifiers

PMID: 18068205
DOI: 10.1016/j.virol.2007.10.045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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