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Article

Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs.

Retrovirology - 8 Jun 2010

Schopman Nick C T, ter Brake Olivier, Berkhout Ben

Abstract excerpt

BACKGROUND: RNA interference (RNAi) is an evolutionary conserved gene silencing mechanism that mediates the sequence-specific breakdown of target mRNAs. RNAi can be used to inhibit HIV-1 replication by targeting the viral RNA genome. However, the error-prone replication machinery of HIV-1 can gen...

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Identifiers

PMID: 20529316
DOI: 10.1186/1742-4690-7-52
PMCID: PMC2898777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20529316-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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