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Article

96 shRNAs designed for maximal coverage of HIV-1 variants.

Retrovirology - 4 Jun 2009

McIntyre Glen John, Groneman Jennifer Lynne, Yu Yi-Hsin, Jaramillo Angel, Shen Sylvie, Applegate Tanya Lynn

Abstract excerpt

BACKGROUND: The RNA interference (RNAi) pathway is a mechanism of gene-suppression with potential gene therapy applications for treating viral disease such as HIV-1. The most suitable inducer of RNAi for this application is short hairpin RNA (shRNA) although it is limited to suppressing a single target. A successful anti-HIV-1 therapy will require combinations of multiple highly active, highly conserved shRNAs to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19497094
DOI: 10.1186/1742-4690-6-55
PMCID: PMC2698899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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