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Article

Lentiviral vectors that carry anti-HIV shRNAs: problems and solutions.

The journal of gene medicine - 1 Sept 2007

ter Brake Olivier, Berkhout Ben

Abstract excerpt

BACKGROUND: HIV-1 replication can be inhibited with RNA interference (RNAi) by expression of short hairpin RNA (shRNA) from a lentiviral vector. Because lentiviral vectors are based on HIV-1, viral sequences in the vector system are potential targets for the antiviral shRNAs. Here, we investigated all possible routes by which shRNAs can target the lentiviral vector system. METHODS: Expression cassettes for...

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Identifiers

PMID: 17628029
DOI: 10.1002/jgm.1078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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