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Article

Human immunodeficiency virus type 1 escape from RNA interference.

Journal of virology - 1 Nov 2003

Boden Daniel, Pusch Oliver, Lee Frederick, Tucker Lynne, Ramratnam Bharat

Abstract excerpt

Sequence-specific degradation of mRNA by short interfering RNA (siRNA) allows the selective inhibition of viral proteins that are critical for human immunodeficiency virus type 1 (HIV-1) replication. The aim of this study was to characterize the potency and durability of virus-specific RNA interference (RNAi) in cell lines that stably express short hairpin RNA (shRNA) targeting the HIV-1 transactivator protein...

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Identifiers

PMID: 14557638
DOI: 10.1128/jvi.77.21.11531-11535.2003
PMCID: PMC229317

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Source receipt: pubmed, retrieved 7 Sept 2026.

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