Article

Ser129 Phosphorylation Paradox: Non-phosphorylated α-Synuclein Drives Parkinson’s Disease-like Pathogenesis <i>in Vivo</i>

2025-12-23

Abstract excerpt

Accumulation of phosphorylated α-synuclein at serine 129 is a hallmark of Parkinson’s disease (PD), but its pathogenic role remains controversial. We conducted longitudinal studies using non-phosphorylatable S129A and phosphomimetic S129D α-synuclein global knock-in mice. Unexpectedly, the S129A mice—rather than S129D mice—developed reproducible olfactory, motor, and cognitive deficits, dopaminergic dysfunction an...

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Literature Corpus work: 891a348f-0030-5fd6-8d92-da61cbe3ef76
DOI: 10.64898/2025.12.21.695762

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