Article

Single-cell Spatial Transcriptional Profiling Uncovers Heterogeneous Cellular Responses to Pathogenic Tau in a Mouse Model of Neurodegeneration

2025-11-19

Abstract excerpt

<h4>Summary</h4> Intracellular tau accumulation contributes to neurodegeneration and systemic dysfunction. Although tau primarily aggregates in neurons as neurofibrillary tangles (NFTs), it also affects other cell types through poorly understood mechanisms. To define the molecular characteristics of tangle-bearing neurons and their influence on surrounding cells, we used CosMx SMI to evaluate the expression of 95...

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Literature Corpus work: a28006e5-ee33-51c2-9f3f-427b0493108d
DOI: 10.1101/2025.11.19.689127

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