Article

Molecular analysis of network vulnerability to α-synuclein pathology reveals PAKs as therapeutic targets for Parkinson’s disease

2024-10-22

Abstract excerpt

<h4>ABSTRACT</h4> α-Synuclein misfolding and progressive accumulation drive a pathogenic process in Parkinson’s disease, yet many brain regions develop more or less pathology than would be predicted by connectivity alone, indicating that intrinsic biological factors influence regional vulnerability. Here, we combined whole brain mapping of α-synuclein pathology in wildtype mice 3 days to 9 months after seeding wi...

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Literature Corpus work: fadb34b0-0f05-5b73-8163-6054f22b639c
DOI: 10.1101/2024.10.22.619411

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