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Article

Alpha-Synuclein in Neurodegeneration: From Shared Biology to Disease-Specific Phenotypes.

Cells - 3 Mar 2026

Su Feifei, Kim Woojin S, Halliday Glenda M, Fu YuHong

Abstract excerpt

Alpha-synuclein (αSyn) is one of the most abundant proteins in the nervous system and is currently associated with devastating synucleinopathies, yet its biology extends far beyond this. In this review, we suggest that αSyn-driven disease emerges within specific neural circuits through the combined effects of cell-type-specific roles, subcellular environments, post-translational modifications (PTMs), and...

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Identifiers

PMID: 41827884
DOI: 10.3390/cells15050451
PMCID: PMC12985178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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