Article

Single-nucleus transcriptomics reveals disease- and pathology-specific signatures in α-synucleinopathies

2023-10-10

Abstract excerpt

α-synucleinopathies are severe neurodegenerative disorders characterized by intracellular aggregation of α-synuclein, yet their molecular pathogenesis remains unknow. Here, we explore cell-specific changes in gene expression across different α-synucleinopathies. We perform single-nucleus RNA sequencing (snRNA-seq) on nearly 300,000 nuclei from the prefrontal cortex of individuals with idiopathic Parkinson’s diseas...

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Literature Corpus work: 0783afac-d398-5165-aea3-5627de915436
DOI: 10.1101/2023.10.10.23296642

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