Back to search

Article

Deletion of CD226 in Foxp3 <sup>+</sup> T cells Reduces Diabetes Incidence in Non-Obese Diabetic Mice by Improving Regulatory T Cell Stability and Function

2022-06-02

Abstract excerpt

Co-stimulation serves as a critical checkpoint for T cell development and activation, and several genetic variants affecting co-stimulatory pathways confer risk for autoimmune diseases. A single nucleotide polymorphism in CD226 ( rs763361 ; G307S) has been shown to increase susceptibility to type 1 diabetes, multiple sclerosis, and rheumatoid arthritis. CD226 competes with the co-inhibitory receptor TIGIT (T cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
fada8b13-3539-598c-aaa4-7ef033d5a66d
DOI
10.1101/2022.06.02.494443
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Deletion of CD226 in Foxp3 <sup>+</sup> T cells Reduces Diabetes Incidence in Non-Obese Diabetic Mice by Improving Regulatory T Cell Stability and FunctionDOI 10.1101/2022.06.02.494443
Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell FunctionSemantic proximity
Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.Semantic proximity
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions.Semantic proximity
Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC.Semantic proximity
Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice.Semantic proximity
Donor-derived CD8 <sup>+</sup> CD122 <sup>+</sup> Tregs generated in mixed donor chimeric NOD mice delete autoreactive T cellsSemantic proximity
A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD mice.Semantic proximity
Selective ablation of thymic and peripheral Foxp3 <sup>+</sup> regulatory T cell developmentSemantic proximity
CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions.Semantic proximity
CD226 deficiency on regulatory T cells aggravates renal fibrosis via up-regulation of Th2 cytokines through miR-340.Semantic proximity
Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice.Semantic proximity
Developmental Heterogeneity of Foxp3⁺ Regulatory T Cells in the Orchestration of Metabolic HomeostasisSemantic proximity
Select a neighboring publication to make it the new centre.