Developmental Heterogeneity of Foxp3⁺ Regulatory T Cells in the Orchestration of Metabolic Homeostasis

Abstract excerpt

Regulatory T (Treg) cells were first identified through the observation that Foxp3 gene mutations in mice and humans can result in their dysfunction, leading to a catastrophic multi-organ autoimmune syndrome. Since then, it has become increasingly evident that Foxp3⁺ Treg cells serve functions extending well beyond dominant tolerance and the mere prevention of autoimmune pathology. Highlighting their pivotal role...

Topics

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• Adipokines, Inflammation, and Metabolic Diseases
• Atherosclerosis and Cardiovascular Diseases
• Cell Lineage
• Cell Survival
• Forkhead Transcription Factors
• Immune Cell Function and Interaction
• Immunomodulation
• T-Lymphocytes, Regulatory

Identifiers and source

Literature Corpus work

4e3f08c4-14aa-5252-a679-053695ad7cc5

DOI

10.20944/preprints202505.0281.v1