Article

Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function

2024-07-19

Abstract excerpt

<h4>Aims/hypothesis</h4> Immunotherapeutics targeting T cells are crucial for inhibiting autoimmune disease progression proximal to disease onset in type 1 diabetes. A growing number of T cell-directed therapeutics have demonstrated partial therapeutic efficacy, with anti-CD3 (α-CD3) representing the only regulatory agency-approved drug capable of slowing disease progression through a mechanism involving the indu...

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Literature Corpus work: 0b868944-5a16-5a05-8121-d3f2a83e0332
DOI: 10.1101/2024.07.16.603756

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