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Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice.

Immunology and cell biology - 1 May 2016

James Cini R, Buckle Irina, Muscate Franziska, Otsuka Masayuki, Nakao Mari, Oon Jack Sh, Steptoe Raymond J, Thomas Ranjeny, Hamilton-Williams Emma E

Abstract excerpt

Enhancement of regulatory T cell (Treg cell) frequency and function is the goal of many therapeutic strategies aimed at treating type 1 diabetes (T1D). The interleukin-2 (IL-2) pathway, which has been strongly implicated in T1D susceptibility in both humans and mice, is a master regulator of Treg cell homeostasis and function. We investigated how IL-2 pathway defects impact Treg cells in T1D-susceptible nonobese...

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PMID: 26763864
DOI: 10.1038/icb.2016.7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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